Humoral Response Decreases in Hemodialysis Patients 6 Months After The Third Dose of COVID-19 Vaccine
Humoral Response in COVID-19 Vaccine
Abstract views: 44 / PDF downloads: 14
DOI:
https://doi.org/10.5281/zenodo.13920454Keywords:
Hemodialysis, COVID-19 vaccine, SARS-CoV-2 antibodyAbstract
Background: This study evaluated the antibody levels six months after the administration of the third dose of the COVID-19 vaccine in hemodialysis patients.
Methods: A total of 52 hemodialysis patients were enrolled in the study. Antibody levels were assessed using the Abbott SARS-CoV-2 immunoassay, designed to detect IgG antibodies targeting the receptor-binding domain of the S1 subunit of the SARS-CoV-2 spike protein.
Results: The incidence of COVID-19 infection within six months following the third vaccine dose was 29.6% (8 patients: 2 males, 25%; 6 females, 75%). Among patients who did not contract COVID-19 within this period, 9 were male (47.4%) and 10 were female (52.6%). There was no statistically significant association between gender and the incidence of COVID-19 within six months post-vaccination (p= 0.280). The median antibody level post-third dose was 7332.4 AU/mL (range: 10.5–40,000), which significantly decreased at the sixth month to 3238.4 AU/mL (range: 17–29,994.7) (p= 0.001). No significant difference between male and female patients was observed in the sixth-month antibody titers (p= 0.744). Furthermore, when analyzed by vaccine type, there was no statistically significant difference in the decline of SARS-CoV-2 IgG antibody levels between recipients of CoronaVac/Sinovac and BNT162b2 (Pfizer/BioNTech) [median (min-max) antibody levels: CoronaVac/Sinovac 2398.2 AU/mL (59.2–38,981.5); BNT162b2 (Pfizer/BioNTech) 11,325.7 AU/mL (17–40,000), (p= 0.181)] at the end of the sixth month.
Conclusion: Antibody titers in hemodialysis patients significantly decreased by the end of the sixth month following the third dose of the SARS-CoV-2 vaccine, independent of the vaccine type. This decline highlights the potential necessity for additional booster doses to enhance and maintain immune protection against SARS-CoV-2 in this vulnerable population.
References
Gupta D, Sahoo AK, Singh A. Ivermectin: potential candidate for the treatment of Covid 19. Braz J Infect Dis. 2020;24(4):369-371. doi:10.1016/j.bjid.2020.06.002
Chavda VP, Kapadia C, Soni S, et al. A global picture: therapeutic perspectives for COVID-19. Immunotherapy. 2022;14(5):351-371. doi:10.2217/imt-2021-0168
Ozturk S, Turgutalp K, Arici M, et al. Mortality analysis of COVID-19 infection in chronic kidney disease, haemodialysis and renal transplant patients compared with patients without kidney disease: a nationwide analysis from Turkey. Nephrol Dial Transplant. 2020;35(12):2083-2095. doi:10.1093/ndt/gfaa271
Lin YC, Lai TS, Lin SL, Chen YM, Chu TS, Tu YK. Outcomes of coronavirus 2019 infection in patients with chronic kidney disease: a systematic review and meta-analysis. Ther Adv Chronic Dis. 2021;12:2040622321998860. Published 2021 Mar 19. doi:10.1177/2040622321998860
Baradaran HR, Dehghanbanadaki H, Moradpour F, et al. The effect of COVID-19 mRNA vaccines against postvaccination laboratory-confirmed SARS-CoV-2 infection, symptomatic COVID-19 infection, hospitalization, and mortality rate: a systematic review and meta-analysis. Expert Rev Vaccines. 2022;21(10):1455-1464. doi:10.1080/14760584.2022.2102001
Yen CC, Lin SY, Chen SC, Chiu YW, Chang JM, Hwang SJ. COVID-19 Vaccines in Patients with Maintenance Hemodialysis. J Pers Med. 2021;11(8):789. Published 2021 Aug 12. doi:10.3390/jpm11080789
Sanders JF, Bemelman FJ, Messchendorp AL, et al. The RECOVAC Immune-response Study: The Immunogenicity, Tolerability, and Safety of COVID-19 Vaccination in Patients With Chronic Kidney Disease, on Dialysis, or Living With a Kidney Transplant. Transplantation. 2022;106(4):821-834. doi:10.1097/TP.0000000000003983
Chen JJ, Lee TH, Tian YC, Lee CC, Fan PC, Chang CH. Immunogenicity Rates After SARS-CoV-2 Vaccination in People With End-stage Kidney Disease: A Systematic Review and Meta-analysis. JAMA Netw Open. 2021;4(10):e2131749. Published 2021 Oct 1. doi:10.1001/jamanetworkopen.2021.31749
Caillard S, Thaunat O. COVID-19 vaccination in kidney transplant recipients. Nat Rev Nephrol. 2021;17(12):785-787. doi:10.1038/s41581-021-00491-7
Goel RR, Painter MM, Apostolidis SA, et al. mRNA vaccines induce durable immune memory to SARS-CoV-2 and variants of concern. Science. 2021;374(6572):abm0829. doi:10.1126/science.abm082
GeurtsvanKessel CH, Geers D, Schmitz KS, et al. Divergent SARS-CoV-2 Omicron-reactive T and B cell responses in COVID-19 vaccine recipients. Sci Immunol. 2022;7(69):eabo2202. doi:10.1126/sciimmunol.abo2202
Levin EG, Lustig Y, Cohen C, et al. Waning Immune Humoral Response to BNT162b2 Covid-19 Vaccine over 6 Months. N Engl J Med. 2021;385(24):e84. doi:10.1056/NEJMoa2114583
SARS‐CoV‐2 Immunoassay. Accessed November 6, 2022. https://www.corelaboratory.abbott/int/en/offerings/segments/infectious-disease/sars-cov-2.
Berar-Yanay N, Freiman S, Shapira M, et al. Waning Humoral Response 3 to 6 Months after Vaccination with the SARS-COV-2 BNT162b2 mRNA Vaccine in Dialysis Patients. J Clin Med. 2021;11(1):64. Published 2021 Dec 23. doi:10.3390/jcm11010064
Davidovic T, Schimpf J, Abbassi-Nik A, et al. Waning humoral response 6 months after SARS-CoV-2 vaccination with the mRNA-BNT162b2 vaccine in hemodialysis patients: time for a boost. Kidney Int. 2021;100(6):1334-1335. doi:10.1016/j.kint.2021.10.006
Beilhack G, Monteforte R, Frommlet F, Reindl-Schwaighofer R, Strassl R, Vychytil A. Humoral Response to mRNA-1273 SARS-CoV-2 Vaccine in Peritoneal Dialysis Patients: Is Boostering After Six Months Adequate?. Front Med (Lausanne). 2022;9:905798. Published 2022 Jun 24. doi:10.3389/fmed.2022.905798
Yavuz D, Karagöz Özen DS, Demirağ MD. COVID-19: mortality rates of patients on hemodialysis and peritoneal dialysis. Int Urol Nephrol. 2022;54(10):2713-2718. doi:10.1007/s11255-022-03193-6
Yavuz D, Karagöz Özen DS, Başbulut E, Bilgin M, Demirag MD. Vaccination Against SARS-CoV-2 and Mortality in Hemodialysis Patients: Three is Good. BSJ Health Sci. 2023;6(3):398-403. doi:10.19127/bshealthscience.1274888
Seagle EE, Bednarczyk RA, Hill T, et al. Measles, mumps, and rubella antibody patterns of persistence and rate of decline following the second dose of the MMR vaccine. Vaccine. 2018;36(6):818-826. doi:10.1016/j.vaccine.2017.12.075
Dan JM, Mateus J, Kato Y, et al. Immunological memory to SARS-CoV-2 assessed for up to 8 months after infection. Science. 2021;371(6529):eabf4063. doi:10.1126/science.abf4063
Vanshylla K, Di Cristanziano V, Kleipass F, et al. Kinetics and correlates of the neutralizing antibody response to SARS-CoV-2 infection in humans. Cell Host Microbe. 2021;29(6):917-929.e4. doi:10.1016/j.chom.2021.04.015
Bergwerk M, Gonen T, Lustig Y, et al. Covid-19 Breakthrough Infections in Vaccinated Health Care Workers. N Engl J Med. 2021;385(16):1474-1484. doi:10.1056/NEJMoa2109072
Khoury DS, Cromer D, Reynaldi A, et al. Neutralizing antibody levels are highly predictive of immune protection from symptomatic SARS-CoV-2 infection. Nat Med. 2021;27(7):1205 1211. doi:10.1038/s41591-021-01377-8
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