Outcomes of Deceased Donor Kidney Transplantation: A Single-Center Experience from Turkiye
Deceased Donor Kidney Transplantation
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https://doi.org/10.5281/zenodo.11215224Keywords:
Kidney transplantation, deceased donor, survival, ESRD, mortality, TurkiyeAbstract
Background: In Turkey, approximately 90% of kidney transplants are conducted utilizing allografts from living donors. Due to the low incidence of cadaveric kidney transplants in the country, comprehensive data on the short-term and long-term outcomes of these procedures remain limited. We aim to present the outcomes of deceased donor-related kidney transplantations (DDKTs) performed in our center.
Methods: This retrospective single-center study was conducted at Atilim University School of Medicine-affiliated Medicana International Ankara Hospital. We analyzed DDKTs performed since 2010. Recipients’ demographical features, one and five-year recipient and allograft survival rates, functions of surviving allografts, rates of primary non-functioning graft, and delayed graft function were noted.
Results: Among 1155 transplants performed between 2010 and 2023, 83 (7.2%) were DDKTs. Recipients were followed-up mean of 84 months. The one- and five-year survival rates for recipients were 94.0% and 81.2%, respectively, while the survival rates for allografts were 89.2% and 72.7%, respectively. Recipient and allograft survival rates were comparable between genders. The optimal allograft function is observed between one and five years post-transplantation; thereafter, a decline in allograft function is typically noted.
Conclusion: Our study demonstrates promising survival rates for recipients of DDKTs in our center, emphasizing the efficacy of this treatment modality for ESRD patients. DDKT can provide substantial dialysis-free survival for most patients with ESRD.
References
Abecassis M, Bartlett ST, Collins AJ, et al. Kidney transplantation as primary therapy for end-stage renal disease: a National Kidney Foundation/Kidney Disease Outcomes Quality Initiative (NKF/KDOQITM) conference. Clin J Am Soc Nephrol. 2008;3(2):471-480. doi:10.2215/CJN.05021107
Thongprayoon C, Hansrivijit P, Leeaphorn N, Acharya P, Torres-Ortiz A, Kaewput W, Kovvuru K, Kanduri SR, Bathini T, Cheungpasitporn W. Recent Advances and Clinical Outcomes of Kidney Transplantation. J Clin Med. 2020 Apr 22;9(4):1193. doi: 10.3390/jcm9041193. PMID: 32331309; PMCID: PMC7230851.
Lentine KL, Schnitzler MA. The economic impact of addressing the organ shortage with clinically high-risk allografts. Mo Med. 2011 Jul-Aug;108(4):275-9. PMID: 21905445; PMCID: PMC6188414.
Haberal M. Transplantation in Turkey. Clin Transpl. 2013;175-180.
Registry of the Nephrology, Dialysis and Transplantation in Turkey 2022. https://nefroloji.org.tr/uploads/pdf/REGISTRY2022_web.pdf, Accessed at: 03.05.2024
Andacoglu O, Aki FT. Global Perspective on Kidney Transplantation: Turkey. Kidney360. 2021;2(7):1160-1162. Published 2021 May 12. doi:10.34067/KID.0002542021
Sevmis M, Demir ME, Merhmatsiz O, Uyar M, Sevmis S, Aktas S. Is Obesity an Obstacle to Being A kidney Donor? Experiences from A High-Volume Center. J Eur Int Med Prof. 2023,1:11-15.
Seyahi N, Kocyigit İ, Eren N, et al. Current status of kidney replacement therapy in Türkiye: A summary of 2022 Turkish Society of Nephrology registry report. Turk J Nephrol. 2024;33(2):134-139.
Aikawa A. Current status and future aspects of kidney transplantation in Japan. Ren Replace Ther. 2018;4:1–12.
Mudiayi D, Shojai S, Okpechi I, et al. Global Estimates of Capacity for Kidney Transplantation in World Countries and Regions. Transplantation. 2022;106(6):1113-1122. doi:10.1097/TP.0000000000003943
Pippias M, Stel VS, Arnol M, et al. Temporal trends in the quality of deceased donor kidneys and kidney transplant outcomes in Europe: an analysis by the ERA-EDTA Registry. Nephrol Dial Transplant. 2021;37(1):175-186. doi:10.1093/ndt/gfab156
Organ Procurement and Transplantation Network. A Guide to Calculating and Interpreting the Kidney Donor Profile Index (KDPI). https://optn.transplant.hrsa.gov/media/1512/guide_to_calculating_interpreting_kdpi.pdf (23 June 2021, date last accessed)
Ceretta ML, Noordzij M, Luxardo R, et al. Changes in co-morbidity pattern in patients starting renal replacement therapy in Europe-data from the ERA-EDTA Registry. Nephrol Dial Transplant. 2018;33(10):1794-1804. doi:10.1093/ndt/gfx355,
Boenink R, Stel VS, Waldum-Grevbo BE, et al. Data from the ERA-EDTA Registry were examined for trends in excess mortality in European adults on kidney replacement therapy. Kidney Int. 2020;98(4):999-1008. doi:10.1016/j.kint.2020.05.039
Donation and Transplantation Institute: International Registry in Organ Donation and Transplantation. Available at: https://www.irodat.org/?p=publications. Accessed May 21, 2021
Tonelli M, Wiebe N, Knoll G, et al. Systematic review: kidney transplantation compared with dialysis in clinically relevant outcomes. Am J Transplant. 2011;11(10):2093-2109. doi:10.1111/j.1600-6143.2011.03686.x
Ojo AO, Morales JM, González-Molina M, et al. Comparison of the long-term outcomes of kidney transplantation: USA versus Spain. Nephrol Dial Transplant. 2013;28(1):213-220. doi:10.1093/ndt/gfs287
Park JI, Jang Y, Park H, Pyun S, Cho HR, Park SJ. A nationwide study of regional preference and graft survival of kidney transplantation in South Korea: patterns of centralization in the capital area. Ann Surg Treat Res. 2024;106(1):11-18. doi:10.4174/astr.2024.106.1.11
Soylu H, Oruc M, Demirkol OK, et al. Survival of renal transplant patients: data from a tertiary care center in Turkey. Transplant Proc. 2015;47(2):348-353. doi:10.1016/j.transproceed.2014.10.054
Ö Merhametsiz, ME Demir. Outcomes of delayed graft function in deceased donor kidney transplantation: a single center experience. J Health Sci Med. 2021;4(1):109-114. doi:10.32322/jhsm.856308
Naylor KL, Kim SJ, McArthur E, Garg AX, McCallum MK, Knoll GA. Mortality in Incident Maintenance Dialysis Patients Versus Incident Solid Organ Cancer Patients: A Population-Based Cohort. Am J Kidney Dis. 2019;73(6):765-776. doi:10.1053/j.ajkd.2018.12.011
Ayar Y, Ersoy A, Ocakoglu G, et al. Risk Factors Affecting Graft and Patient Survivals After Transplantation From Deceased Donors in a Developing Country: A Single-Center Experience. Transplant Proc. 2017;49(2):270-277. doi:10.1016/j.transproceed.2016.12.009
Merhametsiz Ö, Demir ME, Sevmiş M, Uyar M, Aktaş S, Sevmiş Ş. First-year mortality in living donor kidney transplantation: twelve-year experience from a single center. J Health Sci Med. 2021;4(3):252-256
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Copyright (c) 2024 Merter Gülen, Ahmet Cihangir Emral, Mehmet Emin Demir, Gülçin Türkmen Sarıyıldız, Ulaş Sözener, Aylin Yeşim Burç, Öykü Kilci, Siren Sezer
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