Targeted Treatment Strategies and Medication Management for Rheumatic Diseases During Pregnancy and Lactation: A Comprehensive Review
Rheumatic Diseases in Pregnancy and Lactation
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https://doi.org/10.5281/zenodo.13955951Keywords:
Immune-mediated rheumatic diseases, Pregnancy, Preconception Counseling, Medication Safety, Autoimmune Disorders in PregnancyAbstract
Pregnancy in women with immune-mediated rheumatic diseases poses significant challenges, including risks for both maternal and fetal adverse outcomes. This comprehensive review addresses the management of immune-mediated rheumatic diseases during pregnancy and lactation, focusing on medication strategies and treatment protocols to optimize pregnancy outcomes. The continuation or cessation of medications, including biologics and immunosuppressants, is a critical factor in managing disease activity while minimizing fetal risks. The review also explores the use of assisted reproductive technologies, fertility preservation methods for patients undergoing gonadotoxic treatments, and hormone replacement therapy. Additionally, the management of pregnancy in patients with conditions such as systemic lupus erythematosus, antiphospholipid syndrome, and Sjögren’s syndrome is discussed. Key recommendations from the American College of Rheumatology 2020 guidelines are provided, outlining best practices for medication use during pre-conception, pregnancy, and postpartum care. The review underscores the importance of individualized treatment plans and interdisciplinary collaboration to ensure favorable outcomes for both mother and child.
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