Acute Pancreatitis After a Late Period of Metformin Intoxication in a Non-diabetic Patient

Pancreatitis and Metformin


Abstract views: 241 / PDF downloads: 72

Authors

DOI:

https://doi.org/10.5281/zenodo.7562216

Keywords:

acute pancreatitis, metformin, intoxication

Abstract

Metformin, an oral antidiabetic drug, is the first-line treatment modality for the treatment of non-insulin-dependent diabetes mellitus. Metformin is more commonly associated with gastrointestinal side effects. Acute pancreatitis due to metformin is very rare. We present a case of acute pancreatitis after a late period of metformin intoxication in a non-diabetic patient. Because acute pancreatitis can appear in the late period of metformin intoxication, the emergency physician should be vigilant for this condition.

References

Scheen AJ, Paquot N. Metformin revisited: a critical review of the benefit-risk balance in at-risk patients with type 2 diabetes. Diabetes Metab. 2013;39(3):179-190. doi:10.1016/j.diabet.2013.02.006

Timbrell S, Wilbourn G, Harper J, Liddle A. Lactic acidosis secondary to metformin overdose: a case report. J Med Case Rep. 2012;6:230. Published 2012 Aug 2. doi:10.1186/1752-1947-6-230

Gonzalez-Perez A, Schlienger RG, Rodríguez LA. Acute pancreatitis in association with type 2 diabetes and antidiabetic drugs: a population-based cohort study. Diabetes Care. 2010;33(12):2580-2585. doi:10.2337/dc10-0842

Mallick S. Metformin induced acute pancreatitis precipitated by renal failure. Postgrad Med J. 2004;80(942):239-240. doi:10.1136/pgmj.2003.011957

Nitsche C, Maertin S, Scheiber J, Ritter CA, Lerch MM, Mayerle J. Drug-induced pancreatitis. Curr Gastroenterol Rep. 2012;14(2):131-138. doi:10.1007/s11894-012-0245-9

Audia P, Feinfeld DA, Dubrow A, Winchester JF. Metformin-induced lactic acidosis and acute pancreatitis precipitated by diuretic, celecoxib, and candesartan-associated acute kidney dysfunction. Clin Toxicol (Phila). 2008;46(2):164-166. doi:10.1080/15563650701355314

Fimognari FL, Corsonello A, Pastorell R, Antonelli-Incalzi R. Metformin-induced pancreatitis: A possible adverse drug effect during acute renal failure. Diabetes Care. 2006;29(5):1183. doi:10.2337/diacare.2951183

Long YC, Zierath JR. AMP-activated protein kinase signaling in metabolic regulation. J Clin Invest. 2006;116(7):1776-1783. doi:10.1172/JCI29044

Richards SK, Parton LE, Leclerc I, Rutter GA, Smith RM. Over-expression of AMP-activated protein kinase impairs pancreatic {beta}-cell function in vivo. J Endocrinol. 2005;187(2):225-235. doi:10.1677/joe.1.06413

Jagia M, Taqi S, Hanafi M. Metformin poisoning: A complex presentation. Indian J Anaesth. 2011;55(2):190-192. doi:10.4103/0019-5049.79890

Downloads

Published

2023-01-26

How to Cite

KARAAHMET, F. (2023). Acute Pancreatitis After a Late Period of Metformin Intoxication in a Non-diabetic Patient: Pancreatitis and Metformin. Journal of European Internal Medicine Professionals, 1(1), 20–22. https://doi.org/10.5281/zenodo.7562216