Comparison of The Gastrointestinal Side Effects of Selective COX-2 Inhibitor Celecoxib and Indomethacin in Patients With Osteoarthritis

NSAIDs and Gastric Findings

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  • Sibel Ada Istanbul Prof. Dr. Cemil Taşçıoğlu City Hospital, Department of Nephrology, Istanbul, Türkiye
  • Fatma Laika Karabulut Istanbul Prof. Dr. Cemil Taşçıoğlu City Hospital, Department of Gastroenterology, Istanbul, Türkiye
  • Melek Özer Istanbul Prof. Dr. Cemil Taşçıoğlu City Hospital, Department of Rheumatology, Istanbul, Türkiye



Nonsteroidal anti-inflammatory drugs, gastroduodenal lesions, celecoxib, indomethacin, proton pump inhibitors


Background: Nonsteroidal anti-inflammatory drugs are commonly prescribed for osteoarthritis management but are associated with gastrointestinal (GI) adverse events. This study aimed to compare GI findings in patients receiving indomethacin and celecoxib for osteoarthritis.

Methods: A retrospective analysis was conducted on 50 patients (42 females, 8 males) with osteoarthritis, divided into indomethacin (n=25) and celecoxib (n=25) groups. Clinical data, including age, gender, disease duration, and H. pylori status, were collected. Baseline and post-treatment gastroduodenoscopy findings were compared between groups.

Results: No cases of GI bleeding were reported. Indomethacin use was associated with a higher risk of gastroduodenal lesions compared to celecoxib (p<0.05). Celecoxib combined with proton pump inhibitors (PPIs) showed a slight improvement in gastric lesions. H. pylori prevalence was 86% in the study population.

Conclusion: Despite the absence of GI adverse events, indomethacin use posed a higher risk of gastroduodenal lesions compared to celecoxib. The addition of PPIs appeared to mitigate GI adverse events, particularly in the celecoxib group. Individualized treatment approaches balancing therapeutic benefits and potential adverse effects are essential in osteoarthritis management. Further research with larger sample sizes and longer follow-up durations is warranted to validate these findings.


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How to Cite

Ada, S., Karabulut, F. L., & Özer, M. (2024). Comparison of The Gastrointestinal Side Effects of Selective COX-2 Inhibitor Celecoxib and Indomethacin in Patients With Osteoarthritis: NSAIDs and Gastric Findings . Journal of European Internal Medicine Professionals, 2(2).