Retrospective Analysis of Prognostic Factors in Patients with Small Cell Lung Cancer
Prognosis in Small Cell Lung Cancer
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https://doi.org/10.5281/zenodo.7772698Keywords:
Small cell lung cancer, prognostic factors, survival, lung cancerAbstract
Background: The goal of this study is to examine how small cell lung cancer (SCLC) prognosis and survival are impacted by pre-treatment clinical characteristics and laboratory data.
Material and Method: The 118 patients diagnosed with SCLC in our center between August 2000 and December 2008 were evaluated retrospectively. The effects of the 19 variables [hemoglobin (Hgb), lactate dehydrogenase (LDH), alkaline phosphatase (ALP), albumin, sedimentation, sodium (Na), neuron-specific enolase (NSE), carcinoembryonic antigen (CEA), cancer antigen 15-3 (CA 15-3), cancer antigen 125 (CA 125), cancer antigen 19-9 (CA 19-9), alpha-fetoprotein (AFP), performance status (PS), stage, sex, weight loss, age, smoking, chemotherapy (CT) related to the prognosis on survival were thoroughly investigated in detail. Statistically, univariate analyses were performed via Kaplan-Meier Method and multivariate analyses were performed via the Cox proportional hazards (Cox PH) model. The covariates that were found to have a significant relation (p<0.05) on prognosis in univariate analyses and the ones with p<0.15 in the univariate analyses were subjected to multivariate analysis to determine independent prognostic factors.
Results: In univariate analyses, albumin, Na, NSE, CA 125, stage, and sex had a significant relation to prognosis (p<0.05). In multivariate analyses, only the stage parameter was found to be an independent predictive factor on prognosis (p=0.019).
Conclusion: The knowledge of prognostic factors like the laboratory and clinical parameters and staging of the patients were considered to have a directing role in determining treatment strategies and clinical follow-up in SCLC.
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